Semaglutide HomeKit – Direct From the Pharmacy
EVERYTHING INCLUDED
Original price was: $599.00.$121.00Current price is: $121.00.
IN STOCK
Home Kit Includes:
1 month supply of Semaglutide/B12 Combination Injection
(Dosage varies from 0.25mg – 2.4mg and is dependent on the Month ordered)
Syringes
Alcohol Pads
Physician Consultation [online]
Pricing:
Month 1 Semaglutide Homekit 0.25mg X 4 Injections – $121
Month 2 Semaglutide Homekit 0.5mg X 4 Injections – $245
Month 3 Semaglutide Homekit 1.0mg X 4 Injections – $295
Month 4 Semaglutide Homekit 1.7mg X 4 Injections, Semaglutide 2.4mg X 1 Injections – $345
Month 5 Semaglutide 2.4mg X 4 Injections (Maintenance) – $395
Procedure
Subqutaneous (Sub-q) Injection, self-administered in fatty abdominal area or thigh.
Video tutorial provided after purchase.
Purpose
Semaglutide Injection is a once-a-week dose that works by mimicking hormones that target areas of the brain involved in regulating appetite and food intake. This can help you eat less and lead to weight loss.
Our Semaglutide is combined with B12 for energy, sleep cycle regulation and a better patient experience,
Dosage and Frequency
Once a week
Taken on the same day each week, any time of day, with or without food.
SEE INGREDIENTS BELOW
(Detailed dosing schedule will be provided with Homekit)
Ingredients:
Month 1 Homekit: Semaglutide 0.25mg X 4 Injections
Month 2 Homekit: Semaglutide 0.5mg X 4 Injections
Month 3 Homekit: Semaglutide 1.0mg X 4 Injections
Month 4 Homekit: Semaglutide 1.7mg X 4 Injections, Semaglutide 2.4mg X 1 Injections
Month 5 Homekit: Semaglutide 2.4mg X 4 Injections (Maintenance)
Diet and Exercise
Healthy eating and activity are recommended.
Benefits
– Weight Loss
– May improve Blood Pressure
– May improve cholesterol
– Improves Blood Sugar
Most Common Side Effect (Full list below)
Nausea
(Recommendations to limit Nausea: Eat bland, low-fat foods, like crackers, toast and rice. Eat foods that contain water, like soup and gelatin. Avoid laying down after eating. Eat slowly. Go outdoors for fresh air.)
Recommended With… (optional)
Fit Shot® HOMEKIT
Reference:
The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials
Inositol and Body Mass
TeleHealth Consultation
A physician may contact you within 24 hours of purchase if additional information is needed.
IMPORTANT!
THIS PRODUCT FOLLOWS A TITRATION SCHEDULE. ALL PATIENTS MUST START WITH ‘MONTH 1’ DOSE. AFTER MONTH 1, THE DOSAGE PER INJECTION INCREASES GRADUALLY IN MONTH 2, 3, AND 4. LASTLY THE MAINTENAINCE DOSE CAN BE ONGOING FOR UP TO 8 MONTHS DEPENDING ON YOUR GOALS
A MINIMUM BMI OF 27 OR GREATER IS REQUIRED TO ORDER THIS PRODUCT
Shipping
This product can be shipped 2-Day or Overnight and does not need to be refrigerated during shipping. As a precaution, please refrigerate once received and opened.
What is Semaglutide?
Semaglutide an incretin mimetic; specifically, semaglutide is a GLP-1 receptor agonist with 94% sequence homology to human GLP-1. Semaglutide binds and activates the GLP-1 receptor. GLP-1 is an important, gut-derived, glucose homeostasis regulator that is released after the oral ingestion of carbohydrates or fats. In patients with Type 2 diabetes, GLP-1 concentrations are decreased in response to an oral glucose load. GLP-1 enhances insulin secretion; it increases glucose-dependent insulin synthesis and in vivo secretion of insulin from pancreatic beta cells in the presence of elevated glucose. In addition to increases in insulin secretion and synthesis, GLP-1 suppresses Glc secretion, slows gastric emptying, reduces food intake, and promotes beta-cell proliferation. The principal mechanism of protraction resulting in the long half-life of semaglutide is albumin binding, which results in decreased renal clearance and protection from metabolic degradation; semaglutide is stabilized against degradation by the DPP-4 enzyme. Semaglutide reduces blood glucose through a mechanism where it stimulates insulin secretion and lowers Glc secretion, both in a glucose-dependent manner. Therefore, when blood glucose is high, insulin secretion is stimulated and Glc secretion is inhibited. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying in the early postprandial phase.
Cyanocobalamin
Cyanocobalamin is a vital compound for cell division and growth, hematopoiesis, and nucleoprotein and myelin synthesis. This vitamin also has an important role in protein synthesis, neural metabolism, DNA and RNA production, as well as fat and carbohydrate metabolism. Several cells appear to have the greatest demand for cyanocobalamin, particularly those that undergo rapid division such as bone marrow and epithelial cells.
Cyanocobalamin binds itself to plasma proteins in the systemic circulation. It attaches with specific cobalamin binding proteins, called transcobalamin I and II, to enter into the tissues. In cells, this vitamin functions as a cofactor for two vital enzymatic reactions: (1) methionine synthase, i.e. the regeneration of methionine from homocysteine and (2) methylmalonyl-CoA mutase, i.e. the isomerization of methylmalonyl-CoA to succinyl-CoA. Both these methylation reactions are vital for growth and cell reproduction.
Methionine, a sulfur-containing, essential amino acid, is a precursor of S-adenosylmethionine, a cofactor for one-carbon metabolism and the final methyl donor for the methylation of DNA, RNA, proteins, and phospholipids.The methionine synthase plays a paramount role in the synthesis of nitrogenous bases (purines and pyrimidines) involved in the formation of DNA. The lack of adequate cobalamin in the body hinders the regeneration of tetrahydrofolate, which eventually leads to megaloblastic anemia due to the functional folate deficiency.On the other hand, the methylmalonyl-CoA mutase helps to metabolize odd chain fatty acids and branch chain amino acids.Cobalamin is also thought to keep the body’s level of sulfhydryl (SH) groups in reduced form. SH groups activate many enzyme systems involved in protein synthesis as well as fat and carbohydrate metabolism. If there is a lack of cobalamin in the body, methylmalonyl CoA accumulates, which presumably leads to the neurological manifestations of B12 deficiency.
The replenishment with parenteral cyanocobalamin causes a rapid and complete improvement of megaloblastic anemia and gastrointestinal symptoms caused by vitamin B12 deficiency. The parenteral administration also halts the progression of neurological damage associated with B12 deficiency, but the complete improvement of the condition may depend on the severity and extent of the deficiency.
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Semaglutide
Semaglutide is a synthetic GLP-1 RA that belongs to a class of antidiabetic agents called incretin mimetics. Incretins are endogenous compounds, including GLP-1, that improve glycemic control once released into the circulation via the gut. Semaglutide subcutaneous injection (Ozempic) and oral tablets (Rybelsus) are used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). Semaglutide subcutaneous injection (Ozempic) is also used to reduce the risk of non-fatal cardiovascular (CV) events and CV mortality in T2DM patients with CV disease. Semaglutide oral tablets demonstrated CV safety by meeting the primary endpoint of non-inferiority for the composite MACE endpoint; the proportion of patients who experienced at least one MACE was 3.8% with semaglutide oral tablets and 4.8% with placebo. However, semaglutide oral tablets are not approved for the reduction of CV events.As with other agents in this class, semaglutide has a boxed warning regarding rodent thyroid C-cell tumor findings and the uncertain relevance to humans.First-line T2DM therapy depends on comorbidities, patient-centered treatment factors, and management needs and generally includes metformin and comprehensive lifestyle modification. Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease. Among the GLP-1 RAs, evidence of CV benefit is strongest for liraglutide, favorable for semaglutide, and less certain for exenatide; there is no evidence of CV benefit with lixisenatide. GLP-1 RAs have high glucose-lowering efficacy, but with variation within the drug class. Evidence suggests that the effect may be greatest for semaglutide once weekly, followed by dulaglutide and liraglutide, closely followed by exenatide once weekly, and then exenatide twice daily and lixisenatide. GLP-1 RAs improve CV outcomes, as well as secondary outcomes such as progression of renal disease, in patients with established CV disease or chronic kidney disease (CKD); these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor. In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy. For patients requiring an injectable medication, GLP-1 RAs are preferred to insulin due to similar or even better efficacy in A1C reduction, lower risk of hypoglycemia, and reductions in body weight. A separate product, semaglutide subcutaneous injection (Wegovy), is indicated as an adjunct to lifestyle modifications for weight loss and chronic weight management in obese (BMI 30 kg/m2 or greater) or overweight adults (BMI 27 kg/m2 or greater) with at least 1 weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia). Four clinical trials for weight management were conducted pre-approval. Depending on the clinical trial, more treated participants lost 5% up to 15% of their initial body weight vs. those taking placebo. According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be offered as chronic treatment along with lifestyle modifications to patients with obesity when the potential benefits outweigh the risks. Short-term pharmacotherapy has not been shown to produce longer-term health benefits and cannot be generally recommended. A generalized hierarchy for medication preferences that would apply to all overweight patients cannot currently be scientifically justified. Individualized weight loss pharmacotherapy is recommended, based upon factors such as the specific characteristics of each weight loss medication, the presence of weight-related complications, and the medical history of the patient.
Cyanocobalamin
Cyanocobalamin is a vitamin of the B-complex family, commonly known as cobalamins (corrinoids). It is a synthetic or man-made form of vitamin B12 that is available as both a prescription and over-the-counter (OTC) medication. Cobalamins exist in several other chemical forms, including hydroxocobalamin, methylcobalamin, and adenosylcobalamin. Cyanocobalamin is the most common form of cobalamins used in nutritional supplements and fortified foods. It contains a cyano (cyanide) group in its structure, which makes it more stable than other forms of vitamin B12 as the cyanide stabilizes the molecule from deterioration. Hydroxocobalamin, however, is the most biologically active form of Vitamin B12; hence, it is more preferable than cyanocobalamin for the treatment of vitamin B12 deficiency.
Cyanocobalamin does not naturally exist in foods owing to the presence of cyanide, which is absent in the natural form of the vitamin. The chemical structure of cyanocobalamin contains the rare mineral cobalt (4.34%), which binds the cyano group and is located in the center of a corrin ring. The commercial manufacturing of the vitamin is done through bacterial fermentation. Compared to other forms of vitamin B12, it is easier to crystallize and more air-stable. Cyanocobalamin is usually obtained as a dark red, amorphous or crystalline powder, orthorhombic needles, or red crystals. The anhydrous form of the compound is highly hygroscopic. It may absorb up to 12% of water if exposed to air. Cyanocobalamin is sparingly soluble in alcohol and water (1 in 80 of water), but insoluble in chloroform, acetone, and ether. The coenzymes of this vitamin are highly unstable in light.
Cyanocobalamin is available in several dosage forms including the tablet, nasal spray, and injection. The US-FDA initially approved the drug in 1942. However, the compound became widely available for routine use in the treatment of B12 deficiency in the early 1950s.
The lack of vitamin B12 may result from any of the following conditions:
- Addisonian (pernicious) anemia — this condition causes autoantibody formation against parietal cells, which results in a lack of IF essential for absorption of vitamin B12 from the intestine
- Malabsorption — impaired absorption of vitamin B12
- Gastrointestinal pathology, dysfunction, or surgery — these include atrophic gastritis, celiac disease, small bowel bacterial overgrowth, pancreatic insufficiency, Helicobacter pylori infection, gastric carcinoma, and total or partial gastrectomy
- Diphyllobothrium latum and related species (the fish tapeworm) infestation — these parasites compete with vitamin B12 for intestinal absorption; this leads to a malabsorption of the vitamin
- Certain medications use — long term metformin use and chronic acid-reducing drugs decrease the absorption of vitamin B12 from food particles
- Malignancy of the pancreas or bowel
- Folic acid deficiency
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Semaglutide
Semaglutide is contraindicated in patients with a history of angioedema, anaphylaxis, or other serious hypersensitivity reaction to semaglutide. There is a risk of serious hypersensitivity reactions with semaglutide. Serious hypersensitivity reactions have also been reported during postmarketing use with other GLP-1 receptor agonists. Use caution in patients with a history of anaphylaxis or angioedema to other GLP-1 receptor agonists because it is unknown whether such patients will be predisposed to serious reactions with semaglutide. If a serious hypersensitivity reaction is suspected, discontinue semaglutide. Treat promptly per standard of care, and monitor until signs and symptoms resolve.
Semaglutide is contraindicated in patients with a personal or family history of certain types of thyroid cancer, specifically thyroid C-cell tumors such as medullary thyroid carcinoma (MTC), or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2). Semaglutide has been shown to cause dose-dependent and treatment duration-dependent malignant thyroid C-cell tumors at clinically relevant exposures in both genders of rats and mice. A statistically significant increase in cancer was observed in rats receiving semaglutide at all dose levels (greater than 2X human exposure). It is unknown whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Cases of MTC in patients treated with liraglutide, another GLP-1 receptor agonist, have been reported in the postmarketing period; the data in these reports are insufficient to establish or exclude a causal relationship between MTC and GLP-1 receptor agonist use in humans. In clinical trials, there were 7 reported cases of papillary thyroid carcinoma in patients treated with liraglutide and 1 case in a comparator-treated patient (1.5 vs. 0.5 cases per 1,000 patient-years). Most of these papillary thyroid carcinomas were less than 1 cm in greatest diameter and were diagnosed after thyroidectomy, which was prompted by finding on protocol-specified screening with serum calcitonin or thyroid ultrasound. Patients should be counseled on the potential risk and symptoms of thyroid tumors (e.g. a mass in the neck, dysphagia, dyspnea or persistent hoarseness). Although routine monitoring of serum calcitonin is of uncertain value in patients treated with semaglutide, if serum calcitonin is measured and found to be elevated, the patient should be referred to an endocrinologist for further evaluation.
Semaglutide should not be used for the treatment of type 1 diabetes mellitus.
Hypoglycemia should be monitored for by the patient and clinician when semaglutide treatment is initiated and continued for type 2 diabetes mellitus (T2DM) and when used for weight reduction and maintenance. In a clinical trial of semaglutide injection for weight loss (Wegovy) in patients with T2DM and a BMI of 27 kg/m2 or more, hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients. One episode of severe hypoglycemia (requiring the assistance of another person) was reported in one semaglutide-treated patient versus no placebo-treated patients. In clinical trials of semaglutide injection for T2DM (Ozempic), hypoglycemia was increased when semaglutide was used in combination with a sulfonylurea; patients receiving semaglutide in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia, including severe hypoglycemia. Although specific dose recommendations are not available, the clinician should consider a dose reduction of the sulfonylurea or insulin when used in combination with Semaglutide. In addition, when semaglutide is used in combination with insulin detemir, the dose of insulin should be evaluated; in patients at increased risk of hypoglycemia consider reducing the dose of insulin at initiation of semaglutide, followed by careful titration. Adequate blood glucose monitoring should be continued and followed. Patient and family education regarding hypoglycemia management is crucial; the patient and patient’s family should be instructed on how to recognize and manage the symptoms of hypoglycemia. Early warning signs of hypoglycemia may be less obvious in patients with hypoglycemia unawareness which can be due to a long history of diabetes (where deficiencies in the release or response to counter regulatory hormones exist), with autonomic neuropathy, intensified diabetes control, or taking beta-blockers, guanethidine, or reserpine. Patients should be aware of the need to have a readily available source of glucose (dextrose, d-glucose) or other carbohydrate to treat hypoglycemic episodes. In severe hypoglycemia, intravenous dextrose or glucose injections may be needed. Because hypoglycemic events may be difficult to recognize in some elderly patients, antidiabetic agent regimens should be carefully managed to obviate an increased risk of severe hypoglycemia. Severe or frequent hypoglycemia in a patient is an indication for the modification of treatment regimens, including setting higher glycemic goals. Semaglutide may have particular benefits when used in patients with T2DM who are overweight. According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be considered as an adjunct to lifestyle therapy in all patients with T2DM as needed for weight loss sufficient to improve glycemic control, lipids, and blood pressure.
Semaglutide has not been studied in patients with a history of pancreatitis to determine whether these patients are at increased risk for pancreatitis. After initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting). If pancreatitis is suspected, discontinue semaglutide; if pancreatitis is confirmed, do not resume semaglutide. Acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with GLP-1 receptor agonists, including semaglutide. The FDA and the EMA have stated that after review of published and unpublished reports, the current data do not support an increased risk of pancreatitis and pancreatic cancer in patients receiving incretin mimetics. The agencies have not reached any new conclusions about safety risks of the incretin mimetics, although they have expressed that the totality of the data that have been reviewed provides reassurance. Continue to consider precautions related to pancreatic risk until more data are available. According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, obese patients receiving incretin-based therapies for weight loss should be monitored for the development of pancreatitis. Incretin-based therapies should be avoided in patients with prior or current pancreatitis; otherwise, there are insufficient data to recommend withholding them for weight loss due to concerns of pancreatitis.
Use semaglutide with caution in patients with known gallbladder disease or a history of cholelithiasis. If cholelithiasis or cholecystitis are suspected in a patient taking semaglutide, gallbladder studies are indicated. Acute gallbladder disease events, such as cholecystitis or cholelithiasis, have been reported in clinical studies. In clinical trials of semaglutide injection for type 2 diabetes mellitus (T2DM), cholelithiasis was reported in 1.5% and 0.4% of patients-treated with semaglutide 0.5 mg and 1 mg subcutaneous injection, respectively. Cholelithiasis was not reported in placebo-treated patients. In clinical trials of semaglutide tablets for T2DM, cholelithiasis was reported in 1% of patients-treated with semaglutide 7 mg tablets. Cholelithiasis was not reported in patients receiving the 14 mg tablets or placebo-treated patients. In clinical trials of semaglutide injection for weight management, cholelithiasis was reported in 1.6% of semaglutide-treated patients compared with 0.7% of placebo-treated patients. Cholecystitis was reported in 0.6% and 0.2% of patients, respectively. Substantial or rapid weight loss can increase the risk of cholelithiasis; however, the incidence of acute gallbladder disease was greater in semaglutide-treated patients than in placebo-treated patients, even after accounting for the degree of weight loss. According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, close monitoring for cholelithiasis is recommended during weight loss therapy, regardless of modality. In high-risk patients, use semaglutide with caution. Effective preventative measures for patients at risk for cholelithiasis include a slower rate of weight loss, increasing/including some dietary fat in the diet (assuming the patient has been on a very low-calorie diet containing little or no fat), or administration of ursodeoxycholic acid.
During semaglutide therapy, patients with a history of diabetic retinopathy should be closely monitored. Inform patients to contact their care team if changes in vision are experienced during treatment. There is an increased risk for diabetic retinopathy complications in patients with a history of diabetic retinopathy at baseline compared to patients without a known history of diabetic retinopathy. In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%). The absolute risk increase for diabetic retinopathy complications was larger among patients with a history of diabetic retinopathy at baseline (semaglutide injection 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide injection 0.7%, placebo 0.4%). In a pooled analysis of glycemic control trials with oral semaglutide, diabetic retinopathy complications occurred in 4.2% of T2DM patients receiving semaglutide and 3.8% with comparator. In a trial of semaglutide injection (Wegovy) in patients with T2DM and BMI of 27 kg/m2 or more, diabetic retinopathy was reported by 4% of semaglutide-treated patients vs. 2.7% of placebo-treated patients. Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy. The effect of long-term glycemic control with semaglutide on diabetic retinopathy complications has not been studied.
Use caution during treatment with semaglutide in patients with renal impairment or end-stage renal disease (renal failure); however, no dose adjustments are needed based on renal function. Use caution and monitor renal function when initiating or increasing doses of semaglutide in patients with renal impairment or any patients who report severe gastrointestinal reactions during use. There have been postmarketing reports of renal impairment, acute kidney injury, and worsening of chronic renal failure, which sometimes has required hemodialysis, in patients treated with GLP-1 receptor agonists. Some of these events have been reported in patients without known underlying renal disease. In many of these cases, altered renal function has been reversed with supportive treatment and discontinuation of potentially causative agents. A majority of the reported events occurred in patients who had experienced nausea, vomiting, diarrhea, or dehydration.
Suicidal behavior and ideation have been reported in clinical trials with other incretin mimetics indicated for weight management. Therefore, when semaglutide is used for weight management, administer with caution in patients with depression and avoid use in patients with a history of suicide attempts or active suicidal ideation; monitor patients for the emergence or worsening of depression, suicidal thoughts or behavior, and any unusual changes in moods or behaviors. Discontinue semaglutide in patients who develop suicidal thoughts or behaviors. According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, all patients undergoing weight loss therapy should be monitored for mood disorders, depression, and suicidal ideation. Caution is recommended in patients with a psychotic disorder (e.g., schizophrenia due to insufficient data. Patients receiving an antipsychotic should be treated with structured lifestyle modifications to promote weight loss and weight gain prevention; these guidelines suggest that metformin may be beneficial for modest weight loss and metabolic improvements in patients receiving an antipsychotic.
Semaglutide (Wegovy) for the treatment of obesity or weight management should not be used during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm due to the potential hazard of maternal weight loss to the fetus. There is a pregnancy exposure registry for women who use semaglutide intended for weight management (Wegovy) during pregnancy. Contact Novo Nordisk at 1-800-727-6500 for more information. According to the American Association of Clinical Endocrinologists the and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications must not be used during pregnancy; these guidelines recommend contraception requirements for patients of childbearing potential; those receiving semaglutide for weight reduction should use adequate contraception and discontinue semaglutide if pregnancy occurs. There are no adequate data or clinical studies of semaglutide use for the treatment of type 2 diabetes mellitus (T2DM) in pregnant women to inform a drug-associated risk for adverse developmental outcomes; use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Rat studies have noted embryofetal mortality, structural abnormalities, and alterations to growth at maternal exposures below the maximum recommended human dose (MRHD) based on exposure AUC. In rabbits and cynomolgus monkeys administered semaglutide during organogenesis, early pregnancy losses and structural abnormalities were observed at below the MRHD (rabbit) and 5-fold or greater the MRHD (monkey). Poorly controlled diabetes during pregnancy also increases fetal risk. In addition, salcaprozate sodium (SNAC), an absorption enhancer in oral semaglutide tablets, crosses the placenta, and reaches fetal tissues in rats. In a pre- and postnatal development study of SNAC exposure, an increase in gestation length, an increase in the number of stillbirths, and a decrease in pup viability were observed. The American College of Obstetricians and Gynecologists (ACOG) and the American Diabetes Association (ADA) continue to recommend human insulin as the standard of care in pregnant women with diabetes mellitus and gestational diabetes mellitus (GDM) requiring medical therapy; insulin does not cross the placenta.
Semaglutide may be associated with reproductive risk and preconceptual planning is recommended; females of childbearing potential should discontinue semaglutide at least 2 months before a planned pregnancy due to the drug’s long washout period.
Use injectable semaglutide with caution during lactation; oral semaglutide therapy is not recommended during breastfeeding. There are no data on the presence of semaglutide in human milk, the effects on the breastfed infant, or the effects on milk production. Semaglutide was present in the milk of lactating rats and was detected at levels 3- to 12- fold lower than in maternal rat plasma. Salcaprozate sodium (SNAC) (an absorption enhancer in oral semaglutide tablets) and/or its metabolites concentrated in the milk of lactating rats. There are no data on the presence of SNAC in human milk. Since the activity of UGT2B7, an enzyme involved in SNAC clearance, is lower in infants compared to adults, higher SNAC plasma levels may occur in neonates and infants. Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC from breastfeeding and because semaglutide injection can be considered for use during lactation, advise patients that breastfeeding is not recommended during treatment with oral semaglutide tablets. If semaglutide is discontinued and blood glucose is not controlled on diet and exercise alone, insulin therapy should be considered. Other oral hypoglycemics may be considered as possible alternatives during breastfeeding. Because acarbose has limited systemic absorption, which results in minimal maternal plasma concentrations, clinically significant exposure via breast milk is not expected. Also, while the manufacturers of metformin recommend against breastfeeding while taking the drug, data have shown that metformin is excreted into breast milk in small amounts and adverse effects on infant plasma glucose have not been reported in human studies. Tolbutamide is usually considered compatible with breastfeeding. Glyburide may also be a suitable alternative since it was not detected in the breast milk of lactating women who received single and multiple doses of glyburide. If any oral hypoglycemics are used during breastfeeding, the nursing infant should be monitored for signs of hypoglycemia, such as increased fussiness or somnolence.
Semaglutide has been studied in adults 65 years of age or older during clinical trials; safety and efficacy were not different in geriatric adults versus younger adults. In general, however, geriatric adults are especially at risk for hypoglycemic episodes. The specific reasons identified include intensive insulin therapy, decreased renal function, severe liver disease, alcohol ingestion, defective counter regulatory hormone release, missing meals/fasting, and gastroparesis. Because hypoglycemic events may be difficult to recognize in some elderly patients, antidiabetic agent regimens should be carefully managed to obviate an increased risk of severe hypoglycemia. Severe or frequent hypoglycemia is an indication for the modification of treatment regimens, including setting higher glycemic goals. The federal Omnibus Budget Reconciliation Act (OBRA) regulates medication use in residents of long-term care facilities (LTCFs). According to OBRA, the use of antidiabetic medications should include monitoring (e.g., periodic blood glucose) for effectiveness based on desired goals for that individual and to identify complications of treatment such as hypoglycemia or impaired renal function.
Cyanocobalamin
Cyanocobalamin is contraindicated in those with hypersensitivity to cobalt moiety or cobalamin molecule due to the risk of anaphylaxis.
Warnings:
The use of cyanocobalamin is warned in patients with early Leber’s disease as there have been reports of severe and swift optic atrophy with its administration. Appropriate caution should be exercised while treating severe megaloblastic anemia with cyanocobalamin as intense treatment may lead to hypokalemia and sudden death. Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity. Formulations of cyanocobalamin injection containing benzyl alcohol as a preservative should also be avoided in premature neonates and those with hypersensitivity due to its association with ‘gasping syndrome.
Monitoring:
A history of the patient’s allergies/hypersensitivity should be obtained before administering cyanocobalamin injection. If the patient is suspected to be sensitive to cobalt or other components of cobalamin, an intradermal test dose is recommended.
Several laboratory tests should be performed prior to treatment with cyanocobalamin, including serum vitamin B12, folate, iron, hematocrit, and reticulocyte count. All these parameters need to be normal before initiating the treatment. Serum levels of vitamin B12 and peripheral blood counts should be monitored in one month. For hematocrit and reticulocyte counts, recommendations are to repeat these tests daily from the 5th to 7th days of treatment and then frequently until the hematocrit returns to a normal range.
Both serum potassium concentrations and the platelet count need to be monitored carefully after parenteral administration of cyanocobalamin. This is because hypokalemia and thrombocytosis could occur due to the increase in erythrocyte metabolism following vitamin B12 therapy. Potassium replacement therapy should be administered if necessary.
Patients with pernicious anemia are three times more likely to have gastric carcinoma compared to general population; thus, appropriate tests need to be carried out to rule out this condition if suspected.Therapeutic response to cyanocobalamin may decrease due to elderly age, infection, renal insufficiency, diabetes mellitus, marrow suppressants use (e.g. chloramphenicol), and concurrent iron or folic acid deficiency. Therefore, these factors should be taken into consideration and regular monitoring should be performed in these conditions while treating vitamin B12 deficiency with cyanocobalamin.
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Semaglutide
In monotherapy trials with semaglutide injection for type 2 diabetes mellitus (T2DM), severe hypoglycemia (requiring the assistance of another person) was not reported in either the treatment group or the placebo group. Documented symptomatic hypoglycemia (glucose of 70 mg/dL or less) was reported in 1.6% to 3.8% of patients receiving semaglutide injection vs. 0% of patients receiving placebo. Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was not reported in any of the patients receiving semaglutide monotherapy compared to 1.6% of patients receiving placebo. In trials where semaglutide was added on to basal insulin with or without metformin, severe hypoglycemia (requiring the assistance of another person) was reported in 1.5% of semaglutide-treated patients. Documented symptomatic hypoglycemia (glucose of 70 mg/dL or less) was reported in 16.7% to 29.8% of patients receiving semaglutide, and severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) was reported in 8.3% to 10.7% of patients receiving semaglutide. Hypoglycemia was more frequent when semaglutide was used in combination with a sulfonylurea; severe hypoglycemia occurred in 0.8% and 1.2% of patients when semaglutide 0.5 mg and 1 mg, respectively, was given with a sulfonylurea; with documented symptomatic hypoglycemia occurred in 17.3% and 24.4% of patients when semaglutide 0.5 mg and 1 mg, respectively. Severe or blood glucose confirmed symptomatic hypoglycemia (glucose of 56 mg/dL or less) occurred in 6.5% and 10.4% of patients when semaglutide 0.5 mg and 1 mg, respectively, when coadministered with a sulfonylurea. In monotherapy trials with semaglutide oral tablets for T2DM, severe hypoglycemia (requiring the assistance of another person) was reported in 1% of patients receiving the 7 mg tablets and 0% of patients receiving the 14 mg tablets or placebo. A blood glucose level of 54 mg/dL or less occurred in 1% of patients receiving placebo and 0% of the semaglutide oral treatment groups. In trials where semaglutide tablets was added on to metformin and/or sulfonylurea, basal insulin alone, or metformin in combination with basal insulin in patients with moderate renal impairment, severe hypoglycemia was not reported in any of the patients in the trial. In contrast, blood glucose level of 54 mg/dL or less occurred in 6% of patients receiving the 14 mg tablets, 3% of patients receiving placebo, and 0% of patients receiving the 7 mg tablets. In trials with semaglutide was added on to insulin with or without metformin, severe hypoglycemia was reported in 1% of patients receiving the 14 mg tablets, 1% of patients receiving placebo, and 0% of the patients receiving the 7 mg tablets. A blood glucose level of 54 mg/dL or less was reported in 26% of patients receiving the 7 mg tablets, 30% of patients receiving the 14 mg tablets, and 32% with placebo. In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients. A higher rate of clinically significant hypoglycemic episodes was reported with the semaglutide 2.4 mg/week dose versus the 1 mg/week dose (10.7 vs. 7.2 episodes per 100 patient-years of exposure, respectively); the rate in the placebo-treated group was 3.2 episodes per 100 patient years of exposure. In addition, one episode of severe hypoglycemia requiring intravenous glucose was reported in a semaglutide-treated patient. The risk of hypoglycemia was increased when semaglutide was used with a sulfonylurea.
As with other GLP-1 analogs, gastrointestinal (GI) events are the most commonly reported adverse effects with semaglutide. More patients receiving semaglutide discontinued treatment due to GI adverse reactions than patients receiving placebo during all clinical trials. The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%). The majority of reports of nausea, vomiting, and/or diarrhea occurred during dose escalation. Appendicitis was reported in 10 (0.5%) semaglutide-treated patients vs. 2 (0.2%) placebo-treated patients during clinical trials of semaglutide injection used for weight management. In the trial with semaglutide 1 mg and 2 mg injection for type 2 diabetes mellitus, GI events occurred more frequently among patients receiving semaglutide 2 mg injection (34%) compared to semaglutide 1 mg injection (30.8%).
Acute gallbladder disease events, such as cholecystitis or cholelithiasis, have been reported in clinical studies with semaglutide. In clinical trials of semaglutide injection for type 2 diabetes mellitus (T2DM), cholelithiasis was reported in 1.5% and 0.4% of patients-treated with semaglutide 0.5 mg and 1 mg subcutaneous injection, respectively. Cholelithiasis was not reported in placebo-treated patients. In clinical trials of oral semaglutide for T2DM, cholelithiasis was reported in 1% of patients-treated with semaglutide 7 mg PO. Cholelithiasis was not reported in patients receiving the 14 mg PO or placebo-treated patients. In clinical trials of semaglutide injection for weight management, cholelithiasis was reported in 1.6% of semaglutide-treated patients compared with 0.7% of placebo-treated patients. Cholecystitis was reported in 0.6% of semaglutide-treated patients (vs. 0.2%, placebo). Substantial or rapid weight loss can increase the risk of cholelithiasis; however, the incidence of acute gallbladder disease was greater in semaglutide-treated patients than in placebo-treated patients, even after accounting for the degree of weight loss. Cholecystectomy has been reported during postmarketing use.
In placebo-controlled trials of semaglutide injection for type 2 diabetes mellitus, fatigue, dysgeusia, and dizziness were reported in greater than 0.4% of semaglutide-treated patients. In placebo-controlled trials of semaglutide injection for weight management, headache (14%), fatigue (11%), and dizziness (8%) were reported in treated patients.
In placebo-controlled trials for type 2 diabetes mellitus, an injection site reaction (e.g., injection-site discomfort, erythema) was reported in 0.2% of patients receiving semaglutide. In clinical trials, 1.4% of patients treated with semaglutide injection for weight management experienced injection site reactions (including injection site pruritus, erythema, inflammation, induration, and irritation) vs. 1% with placebo.
Antibody formation against semaglutide has been reported. In clinical trials with semaglutide injection for type 2 diabetes mellitus (T2DM), 32 (1%) of patients receiving semaglutide tested positive for anti-semaglutide antibodies. Of these 32 semaglutide-treated patients that developed anti-semaglutide antibodies, 19 patients (0.6% of the overall population) developed antibodies cross-reacting with native GLP-1. In clinical trials with semaglutide oral tablets for T2DM, 14 (0.5%) of patients developed anti-semaglutide antibodies. Of the 14 semaglutide-treated patients that developed anti-semaglutide antibodies, 7 patients (0.2% of the overall population) developed antibodies cross-reacting with native GLP-1. In clinical trials with semaglutide injection for weight management, 50 (2.9%) of patients receiving semaglutide tested positive for anti-semaglutide antibodies. Of these 50 semaglutide-treated patients that developed anti-semaglutide antibodies, 28 patients (1.6% of the overall population) developed antibodies cross-reacting with native GLP-1.The in vitro neutralizing activity of the antibodies is uncertain at this time. The incidence of antibodies to semaglutide cannot be directly compared with the incidence of antibodies of other products.
There have been postmarketing reports of acute renal failure (unspecified) and worsening of chronic renal failure, which sometimes has required hemodialysis in patients treated with GLP-1 receptor agonists. Some of these events were reported in patients without known underlying renal disease. A majority of reported events occurred in patients who had experienced gastrointestinal reactions such as nausea, vomiting, diarrhea, or dehydration. In clinical trials of semaglutide injection for weight management, acute kidney injury occurred in 7 patients (0.4 cases per 100 patient-years) receiving semaglutide vs. 4 patients (0.2 cases per 100 patient-years) receiving placebo. The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration. Monitor renal function when initiating or escalating doses of semaglutide in patients reporting severe adverse GI reactions.
In clinical trials of semaglutide for type 2 diabetes mellitus, patients exposed to semaglutide subcutaneous injection reported increases in amylase (hyperamylasemia) and lipase, and had a mean increase from baseline in amylase of 13% and lipase of 22%. These changes were not observed in placebo-treated patients. In trials with semaglutide oral tablets, patients exposed to semaglutide 7 mg and 14 mg oral tablets had a mean increase from baseline in amylase of 10% and 13%, respectively, and lipase of 30% and 34%, respectively. These changes were not observed in placebo-treated patients. In clinical trials of semaglutide injection for weight management, patients treated with semaglutide had a mean increase from baseline in amylase of 16% and lipase of 39%. These changes were not observed in the placebo group. There have been reports of acute pancreatitis in patients taking semaglutide during premarketing trials. In glycemic control trials with semaglutide injection, acute pancreatitis was reported in 7 semaglutide-treated patients (0.3 cases per 100 patient-years) versus 3 in comparator-treated patients (0.2 cases per 100 patient-years). One case of chronic pancreatitis was confirmed in a semaglutide-treated patient. In a 2-year trial, acute pancreatitis was reported in 8 semaglutide-treated patients (0.27 cases per 100 patient-years) and 10 placebo-treated patients (0.33 cases per 100 patient-years), both on a background of standard of care.1 In trials of patients receiving oral semaglutide, pancreatitis was reported as a serious adverse event in 6 patients (0.1 events per 100 patient-years) receiving semaglutide versus 1 in comparator-treated patients (less than 0.1 events per 100 patient-years). In clinical trials of semaglutide injection for weight management, acute pancreatitis was confirmed by adjudication in 4 semaglutide-treated patients (0.2 cases per 100 patient-years) versus 1 in placebo-treated patients (less than 0.1 cases per 100 patient-years). One additional case of acute pancreatitis was confirmed in a patient treated with semaglutide in another clinical trial. The FDA and the EMA have stated that after review of published and unpublished reports, the current data do not support an increased risk of pancreatitis and pancreatic cancer in patients receiving incretin mimetics. The agencies have not reached any new conclusions about safety risks of the incretin mimetics, although they have expressed that the totality of the data that have been reviewed provides reassurance. Continue to consider precautions related to pancreatic risk until more data are available. After treatment initiation and dose increases, patients should be observed carefully for signs and symptoms of pancreatitis (including persistent severe abdominal pain, sometimes radiating to the back and which may or may not be accompanied by vomiting). Semaglutide has not been studied in patients with a history of pancreatitis to determine whether these patients are at increased risk for pancreatitis.
Hypersensitivity reactions, including anaphylaxis, anaphylactoid reactions, angioedema, rash, and urticaria, have been reported postmarketing with use of semaglutide.
Sinus tachycardia was observed during clinical studies of semaglutide injection for weight management; mean increases in resting heart rate of 1 to 4 beats per minute (bpm) were seen with routine clinical monitoring in semaglutide-treated patients vs. placebo. More patients treated with semaglutide than with placebo had maximum changes from baseline at any visit of 10 to 19 bpm (41% vs. 34%, respectively) and 20 bpm or more (26% vs. 16%, respectively). In placebo-controlled trials for type 2 diabetes mellitus (T2DM), semaglutide injection 0.5 and 1 mg resulted in a mean increase in heart rate of 2 to 3 bpm. There was a mean decrease in heart rate of 0.3 bpm in placebo-treated patients. In placebo-controlled trials of oral semaglutide for T2DM, semaglutide 7 and 14 mg resulted in a mean increase in heart rate of 2 to 3 bpm. There was no change in heart rate in placebo-treated patients. Heart rate should be monitored at regular intervals consistent with usual clinical practice in patients taking semaglutide and patients should inform health care providers of palpitations or feelings of a racing heartbeat while at rest during semaglutide treatment. For patients who experience a sustained increase in resting heart rate while taking semaglutide, the drug should be discontinued. Adverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of semaglutide-treated patients versus 0.4% of placebo-treated patients during clinical trials of the semaglutide injection for weight management. Syncope was reported in 0.8% and 0.2% of patients, respectively. Some reactions were related to gastrointestinal adverse reactions and volume loss associated with semaglutide. Hypotension and orthostatic hypotension were more frequently seen in patients on concomitant antihypertensive therapy.
Hair loss (alopecia) was reported in 3% of patients receiving semaglutide injection for weight management during clinical trials vs. 1% of patients receiving placebo.
Rapid improvement in glucose control has been associated with a temporary worsening of diabetic retinopathy. In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in the patients treated with semaglutide injection (3%) compared to placebo (1.8%). The absolute risk increase for diabetic retinopathy complications was greater among patients with a history of diabetic retinopathy at baseline (semaglutide 8.2%, placebo 5.2%) than among patients without a known history of diabetic retinopathy (semaglutide 0.7%, placebo 0.4%). In a pooled analysis of glycemic control trials with oral semaglutide for T2DM, diabetic retinopathy complications occurred in 4.2% of patients receiving semaglutide vs. 3.8% with comparator. In a trial of patients with T2DM and BMI 27 kg/m2 or more receiving semaglutide injection for weight management, retinal disorders were reported by 6.9% of patients treated with semaglutide 2.4 mg/week, 6.2% of patients treated with semaglutide 1 mg/week, and 4.2% of patients treated with placebo. The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively). The effect of long-term glycemic control with semaglutide on diabetic retinopathy complications has not been studied. Patients with a history of diabetic retinopathy should be monitored for progression of diabetic retinopathy during treatment.
Semaglutide may be associated with the development of a new primary malignancy. Nonclinical studies in rodents of clinically relevant doses of GLP-1 receptor agonists showed dose-related and treatment-duration-dependent increases in the incidence of thyroid C-cell tumors (adenomas and carcinomas). It is unknown whether GLP-1 receptor agonists are associated with thyroid C-cell tumors, including MTC in humans. Patients should be counseled on the risk and symptoms of thyroid tumors (e.g. symptoms may include a mass in the neck, dysphagia, dyspnea or persistent hoarseness). Although routine monitoring of serum calcitonin is of uncertain value in patients treated with semaglutide, if serum calcitonin is measured and found to be elevated, the patient should be referred to an endocrinologist for further evaluation.
Cyanocobalamin
Vitamin B12 is known to be non-toxic even in high doses. The reported adverse reactions following parenteral administration of vitamin B12 include:
- Generalized: Anaphylaxis and death
- Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment; peripheral vascular thrombosis
- Hematological: Polycythemia vera (a rare type of blood cancer)
- Gastrointestinal: Mild, transient diarrhea
- Dermatological: Itching; transitory exanthema (widespread skin rash)
- Miscellaneous: Feeling of swelling of entire body
Ingredients:
Month 1 Homekit: Semaglutide/Cyanocobalamin 0.25/0.125mg X 4 Injections
Month 2 Homekit: Semaglutide/Cyanocobalamin 0.5mg/0.25mg X 4 Injections
Month 3 Homekit: Semaglutide/Cyanocobalamin 1.0mg/0.125mg X 4 Injections
Month 4 Homekit: Semaglutide/Cyanocobalamin 1.7mg/0.25mg X 4 Injections, Semaglutide/Cyanocobalamin 2.4mg X 1 Injections
Month 5 Homekit: Maintenence Dosage (Month 5 and onward) Semaglutide/Cyanocobalamin 2.4mg/0.25mg X 4 Injections
REQUIREMENT: All our at-home kits include a tele-medicine consultation with a physician at no additional cost. Upon approval of the physician, medications are shipped out. If for any reason, the physician does not approve, you will be instantly refunded.After purchase of this product, a physician will call you within 24 hour.
Additional information
Weight | .6 lbs |
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531 reviews for Semaglutide HomeKit – Direct From the Pharmacy
531 reviews for Semaglutide HomeKit - Direct From the Pharmacy
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Your review *
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Dec 30. 2022
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I just started but after my first injection I’m happy to report I got zero of the negative side effects that can happen. Perhaps it’s because of how they mix it with b12? Also great customer service
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Done
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Interested
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Nice info
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Your review *
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I had my first dose 1/7/2023 and as of 1/12/2023 I’m down 8lbs. This is combined with intermediate fasting, a low carb /calorie intake and with a lite workout regimen 3 times a week for 30 minutes. I’m flabbergasted with my results 🙂 in week one. I have a weight-loss goal of 50lb by June , I don’t think I’ll have a issue getting there with this little miracle ;).
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Your review *
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Very hard to get medicine out of vial
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Good product. Controls appetite. Also energy level is higher
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Incredible customer service. I have contacted them many times with questions and they are as nice as can be and so helpful. I will continue to order, and have had great results.
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Helps with your energy and curves your appetite. Would recommend to family and friends.
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This stuff is truly amazing! It took about 2 to 4 days after the 1 week’s shot for me to start to feel any changes. It literally took my hunger away completely! Also took away any cravings and it gives my really good energy. I have tried to lose all the extra weight I put on during Covid (about 30lbs) and nothing has worked well as this. I exercise 3-4 times a week but it’s very hard for me to diet because I’m hypoglycemic. With these injections I feel extremely in balance, no hypoglycemia at all, and no jitters. Im on my third week now, and o already lost 8lbs!
I have not experienced any nausea, or any negative side effects as described. This is a real miracle shot! -
Came promptly and packaged well, easy to order
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Already 6 lbs down. Looking forward to shedding more of this weight.
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Just started using it but i’m already down 5 pounds
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Amazing product went down 6 pounds one week!
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Works immediately. No desire for sweets, potato chips, sugary drinks. Engery and wanting to exercise (love walking) Hard to obtain under other circumstances, however, the price and speed of delivery I am thankful for.
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Great product
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I’m into my first month. I’m happy there are no side effects. The communication at Vitastir is excellent. My questions and concerns as a new patient has been spot on and I’m eagerly anticipating the months to come.
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Finished my first month and feeling good. 5lbs down and minimal side effects besides surprised appetite
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Exceptional service so easy to order, beautiful packaging finally an honest company and prompt delivery!
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Incredible product and company!
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Just started with the first month but already seeing results. Also, very easy transaction and shipping was super fast.
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I have been using this product for 2 weeks so far. It’s been wonderful. My appetite has decreased and I have lost an inch around my waist already. Also no side effects at all except for feeling a tiny bit tired the first day. I have been more motivated to exercise because I’m seeing results and I want to maximize weight loss. This product is a game changer
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I’m so pleased with everything I have ever ordered. Super quick and timely services.
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The process was easy and I received my order on time. Instructions were easy to follow and I’m very happy with my results. I noticed on the first week that my cravings and appetite were under control.
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Very easy and informative consult
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So far so good! Have done 3 doses of first month and have had no negative side effects !!
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Your review *
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It works great!
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Extremely fast service! Highly recommend!!
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Fast! Easy! Safe! Great experience! I highly recommend working with VITAstir, and am grateful for this option to help me with my weight loss journey!
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I’m a new customer/patient and a practicing physician. My experience with your organization has been great. Thank you for making the medication available to me without the usual red tape.
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unfortunately it didn’t help me at all.
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I am losing weight, my blood pressure is down and I feel great after only 3 weeks on the starting dose of Semaglutide! I feel I have a new lease on life. I eat smaller portions, I don’t think about food between meals and I feel less bloated.
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Very quick turnaround time, and responsive customer service. The instructions are very clear, and the process of injection is easy. I have taken three doses and have noticed a difference in my hunger levels and have lost few pounds!
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I appreciate the prompt response to any questions I have. Ordering is always easy and the product arrives in timely fashion.
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Your review *
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Not too sure, it’s been two weeks. Haven’t seen any change. I get dizzy now, periodically. I feel like I get full or bloated feeling faster after eating but I’m still hungry. Didn’t curb appetite or cravings.
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Your review *
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Haven’t experienced any side effects. Easy to administer with clear instructions.
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About to order my 2nd month already feeling the effects
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Getting the meds were fairly easy and administered the same. Down 4 pounds in almost 4 weeks. Looking forward to my next phase of weight loss. Somewhat disappointed I haven’t lost more than that…also haven’t haven’t had loss of appetite either. But I’m determined to keep it moving!
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I am in my first month and love the way I feel. I have more energy and my appetite is definitely suppressed! Excited to see what happens next!
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Great
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I am finishing my first month of these injections and I have lost 4 lbs so far. I am optimistic about the rest of the months and ongoing weight loss.
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Your review *
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Great product. Received quickly and easy to give self shot. First shot 5 days ago. So far down 10 pounds. I workout every day. HIIT training. Low calorie diet. I had headache first day. Definitely controls appetite.
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Coming up on week 3 and have already seen some weight lost. Quick shipping and great communication.
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Approx 6 lb lost in 3 weeks. Was hoping for more. Very easy to email concerns and receive quick replies.
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Been amazing to deal with!! A+
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For this price and compound mixture, you can get a better deal elsewhere. I didn’t notice a single bit of change the first month, but that’s ok because it takes longer and higher doses for that. The product did arrive quickly in very safe packaging.
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Very happy with the end to end experience. Top notch, legitimate access to a weight loss miracle!
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Communication could have been better but, the product works.
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Great customer service. Everything I needed came packaged well. Will order again.
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The lower price helps
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I appreciate the professionalism and quality of the products from VITAstir.
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Took my third shot this week. No side effects, hunger under control and down 8 pounds. Would definitely recommend.
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Excellent service… when i called with questions a human answered everything
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Very easy to order.
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it works, it has some side effects. it made me super emotional
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I have only begun using this, but I feel change beginning as well.
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The change in my appetite is really remarkable. My brain is registering when I’m full, a feeling I haven’t had in 20 years.
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Giving the injections was quite easy and the kit came with everything needed. I’ve done 2 injections so far and my appetite is definitely decreased
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Very easy from initial inquiry to home administration
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So far so good with the weightloss injection. I am confused, however, about the titration schedule, as I thought the full dose is 2.4mg. According to this program the highest dose is 0.85mg. Please advise. Thank you..
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So far this product is working I am excited to continue to see the results.
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Informative video for injection and how to minimize side effects. Easy to order. Will continue with additional months. Quick and easy shipping.
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I’ve gained weight. Zero effect on my appetite.
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I found the process simple and really glad I found Vitastir I do wish it was in the auto injector
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Product works! Please be careful about choosing healthy foods to see results. I lost 10 lbs., in three weeks by eating fruit for breakfast, 4 oz of meat, a bowl of veggies for lunch, and 4 oz of fish and veggies for dinner. Drink plenty of water.
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Great service, quick turn around!
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I can definitely tell that this is helping. I lost 7lbs in my second week.
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Your review *
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Your review *
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Great service! Loving everything!
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Been using for 3 wks. This is helping with cravings and I do feel full quicker. Hoping to get more weight loss in month 2.
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I was a little skeptical at first but within a few days my craving for chocolate and sweets is completely gone. It’s been 3 weeks since I started and I’ve lost about 3 lbs. I actually thought the weight would come off faster. Given more time I’m sure I will see the results i’m looking for.
My negative review: It would have been nice to have a menu plan or suggestions of what to eat and what not to. Also, the product is very pricey. I’m not sure if I’m going to reorder. I think for return customers we should get a discount.
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This has been so easy. Great instructions and fast shipping
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I’m sorry but the product did not curb my appetite or help my weight loss. Would not recommend.
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Satisfied customer so far. I’m down 5lbs in 2 weeks. The side effects have been mild, but worth it to lose weight.
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I’m on my third week and I have to say this product works.
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Just finishing up month 1 and am pleased with initial progress.
Staff is very responsive. -
I really like the product. The injection video is great. Not being a medical professional, I would have like to see what 0.25 ml looks like in a 1 ml needle.
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Your review *
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I have tried to lose weight for the last 2 years. I have finally started doing that! Thanks
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Easy to purchase and shipment came quickly. I’ve lost 6 lbs in my first month. A small amount of nausea has been my only side effect.
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Your review *
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It’s hard to tell if it’s working. I have lost a couple lbs, but it doesn’t really feel easier than if I was just doing my diet and exercise alone. This could also be because I’m only on the initial dose. Trying to decide if it’s worth purchasing the next dose to find out
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Great Product! I am starting to experience weight loss. Easy to use website
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I’m not as hungry all the time, and I didn’t have any side effects to the injections!
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I am extremely happy with the product and the results I have seen in my first 4 weeks. Customer service has been excellent and I am a happy repeat customer. Down 14 pounds in four weeks. No cravings and I am honestly not hungry.
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Pleasantly surprised by both the product and the price!
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Fast. Efficient.Professional. Responsive too.
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Not sure if the substance worked tbh. Didn’t reduce appetite
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Good service from company but the doses made me too sick to do anything.
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Great product. Shipped extremely quickly.
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did not work well for me
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They took the time to make sure what o needed and how to take.
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Too early to see the effects although I believe I am eating less
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This place is great. Easy order, I feel great less hungry.
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I am so happy that I decided to Semaglutide by Vitastir. I have lost 30 lbs in eight weeks!
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Your review *
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Works great and fast shipping
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Loved loved loved the experience with Vitastir. 10000% recommend
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I noticed right away my decrease in appetite and I’ve lost over 8 lbs so far.
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Not sure it’s working. It’s hard to withdrawal into the needle
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Service by the merchant was great. Timely, easy however not sure the product was worthwhile. Did not achieve what the product promised.
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First month and I’m down 4lbs.
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I went through Telehealth. They made the experience easy, informative, and pleasant.
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You are very polite and fast
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Very fast delivery!
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My first month on Semaglutide I have noticed a large decrease in my appetite and I have already lost 8 lbs.
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Absolutely amazing product! I have never felt better! In the past three years, I have birthed three children and I am a stay at home mom in college. I felt like I was running on fumes and then I found this and thought I’d give it a try! So happy I did!
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Took 4 days to get a response
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Happy with this product. Although it is early in my weight loss journey, I can feel a significant decrease in my appetite. I will be using this until I reach my goal, along with dieting and exercising.
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Good appetite suppression and only side effect was a headache the day after I took the shot. Lost about a pound a week, which is great for me especially feeling like it was effortless :). Wish the price was more accessible for longer use.
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Quick process and it works great!
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This definitely works. I’m on the lowest dose and I’m not sure if increasing is necessary or even a good idea.
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It just doesn’t work as well as I hoped
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Perfectly packaged and arrived exactly on time. Easy to use guide for a newbie such as myself. Will continue usage for as long as needed.
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Great experience! Fast delivery and very nice and helpful!
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I have completed 3 weeks of the first vial and the results have been fantastic. I am down 10 pounds and have almost no cravings for sweets and other junk food I used to want all the time. I actually get the sensation of being full with smaller portions and have been able to eat healthier. I look forward to seeing what the next few weeks brings.
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Excellent
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I started at 147.7 four weeks ago and now weigh 146.6 Not really happy with results. But will give it another month to see if I can get better results
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Great fast service. Product works as it should. I would definitely order again
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Received my order promptly and the medication provided is working well
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Fast shipping. Great customer service. Excellent Product
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I still felt hungry. Only lost 4 lbs.
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Excellent communication, product arrived timely and accurately.
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Helped me not be hungry. This allowed me to focus on forming new habits, such as portion control and exercise. I only had a few instances of nausea, but didn’t last long.
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So far loving it!
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Excellent product, fast shipping!
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It is working wonderfully!
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I’ve just completed week 3 with the Semaglutide/B12 injections and I am down 5 pounds. My energy level is fine, nothing crazy, as I was afraid it would be with the B12. My appetite has decreased, not to the poi
Johnna D. –
Morgan –
Fast shipping! Great product.
Elía Reyes –
Jamie T. –
Fast friendly service at a great price.
Anonymous –
Helpful information and prompt delivery of medication, would recommend to friends and family! Happy with my results so far and feel much healthier than before!
Laurie –
Product works well with minimal side effects.
Dominique Y. –
Takes a while to work but I’m now starting to feel the effects. Lost a few lbs!
Sharon T. –
Candice Plowman –
Stacie –
Week three and I’m down almost 10 pounds and starting to feel and look healthier!
Nicole Y. –
I love this company and product
Marina –
Your review *
Patrice Bal –
I havent lost any weight
Stella Mathis –
This is the start of it , but going well so far! Excited to see what happens after a few more months !
Anonymous –
Works well a little sick at times may need to switch to something else
Hailey Parsons –
Was a good starting dose, I didn’t feel any nausea from it.
Anonymous –
Erica –
Alyson E. –
Fast and easy!
Anonymous –
Marrissa L. –
Absolutely love Vitastir!!
VITAstir® –
Thank you!
Mae Panui –
Michael –
Great product; great instructions, and organization
Marianne A. –
Andrell Harris –
Great
Sara Casburn –
Excellent service! Very fast shipping! Only company I will purchase from!
Anonymous –
The weight loss is not fast enough
Anonymous –
Great! Thk you
Linda P. –
I’m excited about losing weight and feeling better. Getting ready to order my refill.
Roberto T. –
Jeffrey OReilly –
Michelle G. –
This product has been really helpful with my weight loss journey. It seems after the age of 60 years; it is even more difficult to lose weight. This is exactly what I needed to compliment reaching my goals.
Deborah V. –
Very happy feel great !
Joseph Museau –
Margelys Puerto –
Perfect
Lisa Petrella –
Vitastir customer service is fantastic and very responsive.
Anonymous –
Easy ordered and fast shipping! On week 3.
Anonymous –
Anonymous –
Fast shipping!
Anonymous –
Effective and works well for a great price!
Wendy –
Came with everything needed, syringes, alcohol pads, arrived on ice. The entire process was simple and easy. Quick shipping and I’ve lost 6 pounds in the first three weeks. Excited for next month!
Christy –
Made things very easy to use
Kristin –
Great product and works! I used a different company before and had horrible side effects and had no side effects with this one!
Hilary J. –
gave me more energy
Linda Sauer –
Anonymous –
Simone Henderson –
It was a good product but I don’t like that they don’t tell you to get the 2nd month that it’s almost $300 you should give ppl the choice to pick from there
Christopher –
Very easy process and fast shipping. With only being on the lowest dose, I noticed some effectiveness from it, but differently will have to increase.
Valerie Martinez –
Anonymous –
Fast service
Diana G. –
The service is very fast and easy to access, excellent prices and product quality.
Claudia –
Dominique S. –
With the proper, realistic diet and minimum exercise, you’ll see a difference.
Jimmy M. –
good
Jennifer S. –
Anonymous –
Kate D. –
I am only on week 2 but I have seen a loss in weight already. I do not get sick like others state they do on competitors brands. I also do not feel hungry but when I do eat, I feel full quicker. So far, I love what I am seeing.
Robert Earnest –
Definitely curbed my appetite
Aimee Perron –
I switched to the trizepitide.
Michelle Lubben –
Great service and fast!
Shauna –
Easy as can be! I had no issues enrolling, the process was simple and my product was delivered directly to my door quickly! Prices are fair if not better than competitors and they always have coupons! Highly recommend!
Bodhi –
Prompt service. Effective product
Nicole Y. –
Fast shipping and great customer service! Any question I had was answered within 12-24hrs
Kate –
Love this company and products.
Anonymous –
Anonymous –
Great quality, fast shipping, excellent customer service.
Anonymous –
Quick delivery and easy to manage website/order
Jessica C. –
Absolutely love this product! First month almost done and I’ve seen amazing progress! Can wait for the next month!
Xenah –
Love this product. I lost 22 pounds in 3 months. Had no side effects. Occasional tiredness but that’s about it. I recommend this to all my friends as it’s the only thing that helped me lose weight. You start to see results after the first month. It helps me eat smaller portion and not crave junk food. I feel great and look healthier. Will continue to reach my weight goal. Cozy, clean facilities and staff are great. Go for it don’t hesitate, it definitely works! It’s got far more health benefits as well.
Anonymous –
The doctors are very friendly and the delivery is quick and fast! The product is easy to use and a good price. Great customer service!
Anonymous –
Love it so far
Ashley S. –
I finally feel like myself again. I’m making the right food choices and not overeating just because I’m stressed. I look better and feel better!!
Chelsea S. –
Genuine product and seamless process!
Stephanie –
Process was quick, easy. Product was shipped quickly. No problems!!
June Schumacher –
Not great
Donna Pacina –
Tobi Peterson –
Mary –
Nelle W. –
Great & fast
Shannon –
Does as advertised! I know it won’t be overnight but as long as I’m willing to put in the work, this product will help with my weight loss/ fitness journey!
Anonymous –
Anonymous –
Rhomda Gardner –
Anonymous –
Coleen Stokes –
I haven’t had good results yet- only on week 3.
Eva C. –
Great I’m ready to order more!
Kellie C. –
Easy application process and timely arrival of product. Clear directions and easy use. Only 3 weeks in so no weight lose yet but I do feel the feeling of fullness and less desire of food.
Kandida Nelson –
This was a great product with results after the first two doses. Definitely purchased month number two.
Natalie H. –
Absolutely amazing service. Easy ordering process and quick shipping and receiving time . Ordered both times on Sunday and my order was here by Tuesday and the most affordable I’ve seen yet.
Trevor –
Brittany O’neill –
Works amazing! I don’t get sick on it.
Anonymous –
Worked really well for me
Renee –
The first month I think has been kind of slow but I’ve done this before and I know there will be more loss the second month. Great customer service!
Sandy –
Only works a few months.
Anonymous –
Anonymous –
So far so good !!! After 3 weeks I’m down a few pounds and my appetite and craving are going down. I can tell this is working so I’m going to continue.
Anonymous –
Lost 5 pounds this month. Thank you.
Clare –
Very easy process!
JENNIFER G. –
3 weeks and Im down 7 lbs!
Irwin –
Easy to use
Anonymous –
Super
Anonymous –
love it ,i have lost 44 lbs no problems or side effects
Alexandra V. –
Service is always GREAT with VITAstir. Product took about a week but works very well!
Anonymous –
Kristen Burns –
Jamie –
It has been working great. I’ve been on it for almost 2 months and have lost 12lbs so far. I can’t do too many activities due to limited mobility, so I’m sure I’d be losing more if I could be more active. But it has been a big help with the weight gain I’ve put on over the past 2 years.
Karen –
My appetite was noticeably decreased by week 3
Alicia Atchison –
Mary Green –
Customer service is great. Product ships fast.
Jennifer –
Easy to order. Customer service always helpful when needed. Good communication!
JoAnn Macklin –
I was approved within hours. My first shipment arrived within three days. I just ordered again and I am waiting on my second shipment. It works great and basically the way I want it too. If you are looking for a great place to get your meds online, this is the place.
Megan –
Hannah –
Lisa –
Each time I’ve had a question, the staff has even very quick to respond and should there be a follow up question, the response is also quick. Love it.
Heather B. –
Anonymous –
Happy so far.
Patty w. –
I feel better since using this . I wish i could get more
Karen Cobane –
Anonymous –
no side effects from it!!
Emily –
100% worth it I’ve lost 10 pounds and it doesn’t make me feel sick! 10/10 recommend!
Anonymous –
Very easy to use and when I did have questions it was a simple process with a quick response and no side effects really
Joe Daugherty –
Good Fast delivery
Christine O. –
I am very happy I decided to keep going.
Amanda A. –
Anonymous –
Amazing customer service and doctor support! It only takes a few minutes to submit information and when they ship the package it comes in a timely manner!
Kristi H. –
Just finishing up month 1, starting week 4 tomorrow, things are going so well I signed up for the recurring shipments today because for the very first time in a long time I have hope of reaching a sustainable normal weight! Starting weight 220, down 7 and counting!
Donna P. –
I have lost 44 lbs. with Vitastir!!
Brenda –
Thank you VITAstir for being with me on my weight loss journey and maintenance. So convenient to be able to order from home, and receive my medications, well prepared and packaged.
Anonymous –
Love this and the great price.
Wendy C. –
Outstanding. Easy instructions and excellent medical care.
Anonymous –
Great product ! It works !
Tonia M. –
Fast shipping. Best price from other on line compound pharmacies I’ve seen. Ordered a lot of shots and never disappointed
Anonymous –
Came quickly
krisstin –
So far so good!
Anonymous –
It’s amazing how the noise around food has lessened since starting this!
Dr. Fanny Pollich Sr. –
Your review *
Anonymous –
Rebekah A. –
Been ordering from here for over a year. So simple and if I have questions they are quick to answer. Thanks!
Anonymous –
Mr. Darrel Towne –
Good so far!
Prof. Petra Paucek II –
Great product and customer service.
Barbara L. –
I’ve used VITAstir a few times and have always been very happy with both the product and the customer service I’ve received. The website is easy to use, and delivery is fast.
Annette –
Shanay Jackson –
Samantha –
Great product and customer service.
Sally Dedeaux –
Karen –
Your review *
Anonymous –
This product works very well. I feel great and confident it will help me with my goal to lose weight.
Anonymous –
Laura –
Excellent company to deal with. Received my order promptly. I’ve lost 10 pounds within the 1st 3 weeks.
Pamela –
Quick response time
Anonymous –
This product is amazing! I felt so much more energy. My journey has been tough balancing exercise and healthy food choices. Since starting this product a month ago it has helped me fuel my energy struggles and also help me maintain a healthy balance. It has been a lifesaver. I feel so much better and my confidence is back. Thank you!
Anonymous –
It works the price is high
Toni –
Very fast and efficient! The support is amazing.
Betty –
Diana –
kevin conley –
Jennell Brown –
I’ve been a loyal fan of VITAstir brand products for several years now, and I must say, they never disappoint.
Samantha YOUNG –
julie –
Just needing month 2
Stewart Roberts –
Verified Buyer –
Received my order quickly. Easy to use directions.
Verified Buyer –
Pleased
Verified Buyer –
This is only my first month using Semaglutide so my hunger is no entirely low but I can tell it’s slightly better.
Verified Buyer –
Convenient and great customer service!
Kristen C. –
Minimal side effects and quick results. Very pleased
Diane C. –
So far it seems to be working, I have had very little nausea
Name * –
How to order?
Verified Buyer –
I’m on my third administration. I’ve felt no side effects, but truth be told, I’ve felt no difference in my appetite either! Gonna keep on going to see if this changes.
Verified Buyer –
lara vantrees –
Eun –
It did reduced hunger. since it‘s a lower dose(first month) it didn’t take your hunger away completely. But it did help with lowering sugar cravings!! I don’t looking for all the sweets anymore! I didn’t have any side effects and so excite about my second month!!!
Fritz Serrano –
info please…
Mary Reynolds –
Susan –
What a great experience. Extremely fast service. After one month, list eight pounds. Fairly low side effects generally only lasting the day after injection. Highly recommend for the service and quality product.
Anonymous –
I have lost 6 pounds in three weeks. Not hungry. No side effects after the first few days .
Michele –
I just finished my last dose of my first month of semaglutide/b12 injections and so far so good. I’ve lost 7 lbs and I feel great!! Looking forward to the 2nd month!
Deanna –
Cynthia W. –
Charissa –
Can tell it’s working, don’t have much of an appetite, also makes me think more about good food choices. Can’t wait to start seeing the results.
Jennifer Maskasky –
Lost 50lbs!
Rebecca –
Shipped quickly and medication works great!
Patricia S. –
Anonymous –
Anonymous –
Company ships quickly. Approval process was quick and easy. The product does help with appetite suppression which was noticed right away. Came with everything you need to administer yourself.
Anonymous –
I am a gym fanatic. I work out 5-6 days a week and eat a relatively healthy vegetarian diet. I packed on the lbs during lock down. After I hit 40 all of a sudden my body refused to lose weight. I continued to put on weight even with frequent exercise and adjustments to calories and macros. I have tried everything with zero results and have been completely frustrated. Decided to try Semaglutide, but didn’t want to tell anyone for fear of being judged. I was scared to death to give myself my first shot, but proud to say I did it (after a 10-minute pep talk)! Just watch the video and you’ll be fine.
During the 4 months of treatment, I have had zero negative side effects. I didn’t feel anything working the first couple shots. I wondered if this is even going to work for me. Then, all of a sudden, one day I noticed I couldn’t eat as much. Semaglutide reduces your appetite significantly. Not sure what other things are going on behind the scenes to aide with the weight loss, but it is working great. I have two shots left and I am down about 40 lbs! The B12 is also great! As a vegetarian, I have to supplement B12 as I tend to be low, so that was an added bonus to the shot.
It is expensive, but if you have tried everything and are not seeing results, this may be for you. VITAstir has been great to work with! Quick and easy to order, prompt shipping, and each package includes the medication in a cold pack, dosage directions, and plenty of syringes and alcohol wipes. I am glad I did it and would do it again if I had to do it all over. I would definitely recommend to my family and friends.
Sara B. –
Vita Stir was very accommodating and answered any questions I had.
theres heimel –
Anonymous –
Good so far!
Anonymous –
I was down 5 lbs after 4 weeks. Had a little bit of nausea but other than that, I felt great.
Aimee Myers –
Anonymous –
Sarah C. –
So far so good.. minimal side effects…on to the next month. Appreciate this company!
Tammy –
Anonymous –
Easy! Hoping that I’ll notice a difference soon, I’ve only done 3 injections (3 weeks) to date.
William Turner –
Very good
Nicole –
Amazing customer service! Quick shipping!
Lisa K. –
Though I felt like it helped with my energy level, I didn’t move the needle with regard to my weight.
Jeannie C. –
I’m getting ready to start month three of semaglutide and I started the fit shot last month. I’ve lost 50 pounds and I’m feeling a lot better about life in general. Great products and services!
Anonymous –
It’s only been 3 weeks but I definitely notice a curb in cravings and appetite for the first few days after a shot.
Anonymous –
Delivery was quick and the consultation only took one day. Love the product so far!
Lindsay C. –
Very easy and rewarding!
Anonymous –
Katherine –
Came super fast and easy communication. Answered my questions when asked!
Michael L. –
down 9 lbs in 3 weeks.
Anonymous –
I think it’s working. Looking forward to the next step up in dose to know for sure.
Anonymous –
Fast great service!! I just ordered my month 2. Excited to continue this journey and they make it so easy
Ashley B. –
The ordering process was very straightforward, and all the instructions and information I needed was provided in a proactive manner. I have been very pleased with the process and results so far.
Andrea –
Very helpful in helping me stay on track with my weight loss goals.
Greg –
Anonymous –
The whole process was very easy, and although I’ve had mild side effects, I’m very happy with my purchase and with all the help that was provided.
Lynda Laferla –
Jamie H. –
It’s only been a week and I’m down 4lbs. I’m a little nauseous but I’ve learned that laying down right after eating makes that worse.
I have had NO fast food cravings at all!!
Anonymous –
Works
Anonymous –
Anonymous –
Anonymous –
Misty Milton –
Michelle –
Very quick painless process and easy delivery. Definitely reordering.
Anonymous –
Anonymous –
Kelly –
Worked great. Fast shipping
Gregory E. –
Great service.
Anonymous –
This product is AMAZING. It has really helped suppress my appetite without the horrible side effects of diet pills. Shipping was FAST – received product WEEKS before anywhere else. Customer service is great too!
Anonymous –
Great product, super fast delivery
Glenda Allred –
Excellent service! My orders are always correct, on time and packaged accordingly.
Mary Colwell –
Anonymous –
Definitely helped curb my appetite.
Anonymous –
Craig Jensen –
Works well
Anonymous –
Michael W. –
The whole process was so easy, worth every penny!
Leigh Edwards –
Amanda W. –
Been very happy with how fast my shipments come
JOEL –
Excellent product and delivery was very fast
Becky B. –
This product really works!
Bryan edy –
Nice
JM –
I’m at three months of semaglutide and down 20 lbs which is 10% of my starting weight. My appetite is much less. I used to constantly feel like I needed to eat, and now I literally just put down the food and walk away when I’m satisfied. Sugary things and salty snacks don’t have the same allure and I’m able to take a bite, realize I didn’t actually want the thing I thought I wanted, and not feel like I’m depriving myself because I want to eat fruits and vegetables instead. I don’t feel like I’m hungry or missing out. I just feel better and not obsessed with eating. Remembering what satisfied feels like is a game changer. I did have a bit of a learning curve in the beginning when I was still eating how I previously did, and every time I overate I got nauseous, but that helped me realize I was overeating. I’m sticking with this (for as long as the weight keeps coming off) until I reach my goal
Dana –
So far, I really like this product (been using it for a month). I have more energy and my appetite has definitely decreased. Shipping was fast as well. Looking forward to my second month!
Anonymous –
I have noticed a decrease in the amount of food I eat per day. I don’t have the cravings for sweets anymore and when I do eat them, they don’t give me the same satisfaction and then crave more. I’ve lost 10 lbs in 3 weeks.
Chelsea –
Product was quickly and promptly processed and shipped.
ANGELIA P. –
Definitely curbs your appetite but it did take about 2 to 3 weeks to really feel the full effects. I have been on the shots for 6 weeks and have lost 10 pounds. I am not working out or watching what I eat though.. The appetite suppressant is excellent once the full effects take place.. It completely stops any cravings I previously had.. The price is high and I only purchase when there is a discount promoted. Definitely worth it if you can afford it..
Anonymous –
This has been the best experience! I ordered and received my package on time with out any issues. I have only had 2 doses so I’m just getting started but so far I see a difference not a huge difference but again I just started. I plan to order again for the following month and I will do another review. If you are thinking about it you should try it it’s really worth your money.
Ioana B. –
Quick delivery, great product
Anonymous –
Very efficient transaction, highly recommend.
Shanon –
Purchased a 3 month program and this is by far the easiest program to follow. I’m into week 3 and I can see the difference this is making. I’ll definitely be continuing on this to reach my goals.
Amy –
I had a seamless experience. Product was shipped very fast. Directions were very well transmitted. I know the product worked because of the changes I felt. But I couldn’t financially continue to purchase the medication. I’m a single mom without health insurance. The monthly price is unreachable for me. I do recommend this company, though! Good luck to you all in your journeys!
Anonymous –
Marcus Robbins –
This is a game changer. I used to think about food all day and would have strong cravings for sweets and chips. Within 2 days the obsession with food stopped. I’m not running to the pantry and stuffing my face. I am in control of what I choose to eat. I lost 5 lbs the first week and I feel amazing. I’m not exhausted and miserable from eating junk every day. I am so thankful I found this. It has given me my hope back.
Rita –
Process very streamlined and timely. I’ve not had any side effects from the product but no positive impact either yet.
Anonymous –
Lost 11 pounds in 3 weeks. Major appetite suppressant. No nausea. Walking on treadmill 30 minutes 3-4 week
Elizabeth –
Great communication about shipping and tracking info. Came super fast and worked great! Highly recommend.
Sheila B. –
Anonymous –
Easy to navigate
Roshan Patel –
Good
kevin conley –
Elizabeth –
Johanna –
Jessica T. –
Great service and fantastic product saw results in the first week!
Leslie B. –
Very happy because it works! Really makes you not hungry!
Linda Carp –
Misty B. –
It took a week but it works!
Dmitry –
I LIKE THE PRODUCT!!!
Michelle –
Ashley H. –
The process was fast and easy. I’ve struggled with weight loss for years. I’m 4 weeks in and pleased with the results.
Carly –
My first vial seemed to work great. I’ve noticed it keeps me full longer and I eat less at each meal.
Crystal –
Excellent start!! 3 weeks in and have seen weight loss results. Excited to continue.
Lindsay –
Super easy; the injection instructions were also simple to follow.
Channel M. –
The best level of service virtually.
Anonymous –
Have not lost weight yet
Brandi B. –
Easy, convenient, and fast shipping
Anonymous –
No side effects thus far!
Annette –
Fast shipping and very responsive in emails.
Edward Bruce –
The Process was very quick and easy. Have lost 10lbs with month 1 and looking forward to keeping up the momentum. Wish the Coupon codes lasted longer. Missed the 20% off by one day when ordering my next month.
Amy T. –
Nicole R. –
So far I haven’t noticed much difference and I’ve been on it a month. . I’m hoping within the next week it will kick in.
Kristen D. –
Big decrease in appetite and lost 6 lbs the first month!
Heather –
It has only been a month but I’m very happy so far. I feel more energy and have fewer cravings!
Anonymous –
Jaime B. –
Rhonda N. –
Laura –
So much more energy. Great beginning week
Bryan –
Great customer service and very quick process. After waiting for over a month to get setup with another provider I found Vitastir and the product was shipped the same day I signed up. Very happy with their service and product.
Denise –
Traci Slade –
Jennifer B. –
Amazing product and experience with physician
Jeje –
Nice
Laurie Malarney –
The semiglutide seems to give me energy and appetite suppressing for the first 3 days after taking the shot but wears off
Nichole M. –
Sarah R. –
I think the combination of the B12 and the semaglutide make it a great way to lose weight and help with the side effects. I found the system easy to use and came overnight. I will continue to be a customer and continue my recommended treatment.
Anonymous –
Renai –
Anonymous –
Has helped curb sugar cravings and has given me good energy. Total of 3 lbs lost in first month.
SALLY –
this seems to be the real deal but it is very costly
Amanda R. –
In 2 weeks I am down 8 lbs.
Leslie –
Jana –
Nicole –
I have more energy and have lost 9lbs in 3 weeks
Staci –
Great service and product! In the first month I have noticed a huge decrease in appetite with an amazing increase in energy. Product is simple to inject and I have experienced minimal side effects.
David –
Linda –
Never felt better while taking this. Down 10 LBS in 4 1/2 weeks
Christie –
Amazing! I have more energy and zero side effects. Arrived immediately. I could not be more pleased.
Anonymous –
Works great!
Cari W. –
Anonymous –
I have only been taking this product for a couple of weeks, but so far I feel less hungry and have more energy. Vitastir is very professional and helpful, I will definitely shop with them again.
Anonymous –
Anonymous –
Anonymous –
Very happy with the product. Easy to use and hassle-free
Belinda –
So happy with this purchase. It has changed my life. I feel in control of my food choices and losing weight. All the food noise I had before with emotional and stress eating has gone. I’m eating to fuel my body. So so happy!
Anonymous –
This did not work at all. I eat healthy and exercise daily. It did not curb my hunger at all. If anything I felt more hungry. If I could of returned this product I would. The last shot I bought from this company I thought the same thing but wanted to give it another go. Don’t waste your money.
Rhonda G. –
Noticeable change. Great energy
Anonymous –
Melissa Cochran –
Penny O. –
I started semaglutide three weeks ago. First dose felt some nausea and fatigue, but that was over within the first week. Will take my fourth dose in two days, which means I’ve been taking this for less than three weeks. Since that time I’ve lost seven lbs. As someone else said, it quietens the food noise in my head. I now eat when I’m hungry, and find that small amounts are quite filling. Will be reordering for a second month.
Tammy –
Great:) so easy and quick to send. Thanks so much!
Anonymous –
I’m down 13lbs in 3 weeks.
Anonymous –
Brittany –
Definitely curved my appetite (5 stars for that) BUT when my vile got low, I couldn’t get the rest of the medication out so I feel I didn’t get my money’s worth and it wasn’t cheap
Nancy C. –
Anonymous –
Reduced appetite and maybe about 5 pounds weight loss after 4 weeks. I’m glad
Anonymous –
I am so happy to have found you. The process is so easy, and I am very happy with the results so far! You guys are a true godsend!
Anonymous –
Nichole S. –
This shot is amazing. Working wonders
Anonymous –
Great product. Easy to use.
Michele M. –
Matt Steinhauer –
Nausea is terrible
Anonymous –
Not sure what to expect, but nothing significant was noticed.
Jermaine –
Kanta –
Love this product, with great results. I will continue with my treatment and many more products.
Alena R. –
Seamless experience, pleasant people
Anonymous –
Arrived quicky in a carefully packed box.
Anonymous –
Super efficient experience! Received product really fast. It was packaged well. I’m on week 3 and this definitely decreases my appetite. When I do eat I get full faster. I was worried about how difficult a shot at home would be but it isn’t hard at all. Highly recommend.
Karen Swanson –
Very pleased with the results, lost several pounds and my sugar is down.
Laurie Pacheco –
It definitely controls my hunger.
Melissa C. –
Definitely helps control appetite, and nice energy boost from the vitamins.
YELENA A. –
kailii –
Medication arrived promptly and was packaged very well. Instructions were clear for me to use and store the medication.
Linda –
Sabrina –
Super easy and fast delivery! Really good service the only thing they never scheduled was my consultation but other than that it was great!!
Debbie B. –
Wonderful Service! Fast Shipping!
Marilyn –
So far so good. Love this product and the service was wonderful. It really works!
Jenni Mims –
Tammy –
I’ve just completed week 3 with the Semaglutide/B12 injections and I am down 5 pounds. My energy level is fine, nothing crazy, as I was afraid it would be with the B12. My appetite has decreased, not to the point of starvation, but rather, a half a sandwich and salad is filling. Excited to start month 2!
Anonymous –
Kathryn –
It is working wonderfully!
Tina G. –
Excellent product, fast shipping!
Traci Taylor-Roberts –
Amber –
So far loving it!
Shelley M. –
Helped me not be hungry. This allowed me to focus on forming new habits, such as portion control and exercise. I only had a few instances of nausea, but didn’t last long.
Laura –
Excellent communication, product arrived timely and accurately.
Anonymous –
Erica Abdul-Halim –
I still felt hungry. Only lost 4 lbs.
Salena –
Fast shipping. Great customer service. Excellent Product
Shavonda Sterling –
Received my order promptly and the medication provided is working well
Anonymous –
Great fast service. Product works as it should. I would definitely order again
deborah grecni-umberg –
I started at 147.7 four weeks ago and now weigh 146.6 Not really happy with results. But will give it another month to see if I can get better results
Anonymous –
Audie –
Excellent
Anonymous –
Anonymous –
I have completed 3 weeks of the first vial and the results have been fantastic. I am down 10 pounds and have almost no cravings for sweets and other junk food I used to want all the time. I actually get the sensation of being full with smaller portions and have been able to eat healthier. I look forward to seeing what the next few weeks brings.
Anonymous –
Great experience! Fast delivery and very nice and helpful!
Carrie Morgan –
Anonymous –
Perfectly packaged and arrived exactly on time. Easy to use guide for a newbie such as myself. Will continue usage for as long as needed.
Dawn Sokolosky –
Elaine Mott –
It just doesn’t work as well as I hoped
Anonymous –
This definitely works. I’m on the lowest dose and I’m not sure if increasing is necessary or even a good idea.
Terri –
Quick process and it works great!
Kathryn Nordlund –
janet kiger –
Krista P. –
Good appetite suppression and only side effect was a headache the day after I took the shot. Lost about a pound a week, which is great for me especially feeling like it was effortless :). Wish the price was more accessible for longer use.
Anonymous –
Happy with this product. Although it is early in my weight loss journey, I can feel a significant decrease in my appetite. I will be using this until I reach my goal, along with dieting and exercising.
Anonymous –
Anonymous –
Anonymous –
Took 4 days to get a response
Meghan Stettner –
Absolutely amazing product! I have never felt better! In the past three years, I have birthed three children and I am a stay at home mom in college. I felt like I was running on fumes and then I found this and thought I’d give it a try! So happy I did!
Nancy W. –
Meghan M. –
Rebecca P. –
My first month on Semaglutide I have noticed a large decrease in my appetite and I have already lost 8 lbs.
Jessica Curtis –
Very fast delivery!
Debra McQueen –
You are very polite and fast
Janise Woodard –
I went through Telehealth. They made the experience easy, informative, and pleasant.
Kim –
First month and I’m down 4lbs.
Jennifer –
Service by the merchant was great. Timely, easy however not sure the product was worthwhile. Did not achieve what the product promised.
Tracy S. –
Not sure it’s working. It’s hard to withdrawal into the needle
Anonymous –
I noticed right away my decrease in appetite and I’ve lost over 8 lbs so far.
Anonymous –
Loved loved loved the experience with Vitastir. 10000% recommend
Anonymous –
Works great and fast shipping
Anonymous –
Kimberly –
Your review *
Nichelle Highsmith –
I am so happy that I decided to Semaglutide by Vitastir. I have lost 30 lbs in eight weeks!
Anonymous –
This place is great. Easy order, I feel great less hungry.
Anonymous –
Dave –
Too early to see the effects although I believe I am eating less
Bryan Clements –
Rhonda B. –
They took the time to make sure what o needed and how to take.
Coleman –
did not work well for me
Anonymous –
Great product. Shipped extremely quickly.
Jill O. –
Good service from company but the doses made me too sick to do anything.
Anonymous –
Not sure if the substance worked tbh. Didn’t reduce appetite
Jamie –
Fast. Efficient.Professional. Responsive too.
Shannon –
Pleasantly surprised by both the product and the price!
ROBIN M. –
I am extremely happy with the product and the results I have seen in my first 4 weeks. Customer service has been excellent and I am a happy repeat customer. Down 14 pounds in four weeks. No cravings and I am honestly not hungry.
Ashley S. –
I’m not as hungry all the time, and I didn’t have any side effects to the injections!
Jacqueline Davis –
Anne C. –
Great Product! I am starting to experience weight loss. Easy to use website
Anonymous –
It’s hard to tell if it’s working. I have lost a couple lbs, but it doesn’t really feel easier than if I was just doing my diet and exercise alone. This could also be because I’m only on the initial dose. Trying to decide if it’s worth purchasing the next dose to find out
Danielle Marie Carbonaro –
Your review *
Kathryn G. –
Easy to purchase and shipment came quickly. I’ve lost 6 lbs in my first month. A small amount of nausea has been my only side effect.
Anonymous –
I have tried to lose weight for the last 2 years. I have finally started doing that! Thanks
Lesleigh Mitchell –
Your review *
Anonymous –
Molly B. –
I really like the product. The injection video is great. Not being a medical professional, I would have like to see what 0.25 ml looks like in a 1 ml needle.
Anonymous –
Just finishing up month 1 and am pleased with initial progress.
Staff is very responsive.
Frances Polidori –
Annie L. –
I’m on my third week and I have to say this product works.
Kia –
Sheila –
Satisfied customer so far. I’m down 5lbs in 2 weeks. The side effects have been mild, but worth it to lose weight.
Laurie Watson –
I’m sorry but the product did not curb my appetite or help my weight loss. Would not recommend.
Jeri –
This has been so easy. Great instructions and fast shipping
Linda –
I was a little skeptical at first but within a few days my craving for chocolate and sweets is completely gone. It’s been 3 weeks since I started and I’ve lost about 3 lbs. I actually thought the weight would come off faster. Given more time I’m sure I will see the results i’m looking for.
My negative review: It would have been nice to have a menu plan or suggestions of what to eat and what not to. Also, the product is very pricey. I’m not sure if I’m going to reorder. I think for return customers we should get a discount.
Anonymous –
Been using for 3 wks. This is helping with cravings and I do feel full quicker. Hoping to get more weight loss in month 2.
Dawn Graham –
Great service! Loving everything!
INGE JAMMINE –
Jack Elder –
Your review *
Edith Reyes –
Your review *
Ashley M. –
I can definitely tell that this is helping. I lost 7lbs in my second week.
Rita –
Anonymous –
Great service, quick turn around!
James –
Anonymous –
Product works! Please be careful about choosing healthy foods to see results. I lost 10 lbs., in three weeks by eating fruit for breakfast, 4 oz of meat, a bowl of veggies for lunch, and 4 oz of fish and veggies for dinner. Drink plenty of water.
Julianne –
I found the process simple and really glad I found Vitastir I do wish it was in the auto injector
Kelly M. –
I’ve gained weight. Zero effect on my appetite.
Elle –
Informative video for injection and how to minimize side effects. Easy to order. Will continue with additional months. Quick and easy shipping.
Tammy M. –
So far this product is working I am excited to continue to see the results.
Spiro –
Kimberly –
So far so good with the weightloss injection. I am confused, however, about the titration schedule, as I thought the full dose is 2.4mg. According to this program the highest dose is 0.85mg. Please advise. Thank you..
VITAstir® –
There are instructions on your bottle. Please email [email protected] For clarification.
Anonymous –
Very easy from initial inquiry to home administration
Anonymous –
Giving the injections was quite easy and the kit came with everything needed. I’ve done 2 injections so far and my appetite is definitely decreased
Anonymous –
FELECIA MUSEAU –
Maureen Sweeney –
The change in my appetite is really remarkable. My brain is registering when I’m full, a feeling I haven’t had in 20 years.
Cheryl G. –
I have only begun using this, but I feel change beginning as well.
Lauren –
it works, it has some side effects. it made me super emotional
Cindy –
Dianna –
Very easy to order.
Anonymous –
Excellent service… when i called with questions a human answered everything
Alex –
Kimberly Wilkerson –
Took my third shot this week. No side effects, hunger under control and down 8 pounds. Would definitely recommend.
Anonymous –
I appreciate the professionalism and quality of the products from VITAstir.
Anonymous –
The lower price helps
Anonymous –
Anonymous –
Great customer service. Everything I needed came packaged well. Will order again.
Jenna H. –
Communication could have been better but, the product works.
Michael P. –
Very happy with the end to end experience. Top notch, legitimate access to a weight loss miracle!
Linda R. –
Erin –
For this price and compound mixture, you can get a better deal elsewhere. I didn’t notice a single bit of change the first month, but that’s ok because it takes longer and higher doses for that. The product did arrive quickly in very safe packaging.
Chantal B. –
Been amazing to deal with!! A+
Anonymous –
Kelley Scott –
Approx 6 lb lost in 3 weeks. Was hoping for more. Very easy to email concerns and receive quick replies.
Margaret Devane –
Shari H. –
Coming up on week 3 and have already seen some weight lost. Quick shipping and great communication.
Sherry –
Great product. Received quickly and easy to give self shot. First shot 5 days ago. So far down 10 pounds. I workout every day. HIIT training. Low calorie diet. I had headache first day. Definitely controls appetite.
Diana Wile –
Gloria –
Your review *
Anonymous –
I am finishing my first month of these injections and I have lost 4 lbs so far. I am optimistic about the rest of the months and ongoing weight loss.
kristina dobrijevic –
Great
Anonymous –
I am in my first month and love the way I feel. I have more energy and my appetite is definitely suppressed! Excited to see what happens next!
Christal R. –
Getting the meds were fairly easy and administered the same. Down 4 pounds in almost 4 weeks. Looking forward to my next phase of weight loss. Somewhat disappointed I haven’t lost more than that…also haven’t haven’t had loss of appetite either. But I’m determined to keep it moving!
Tammy M. –
Marybeth W. –
About to order my 2nd month already feeling the effects
Ashley –
Haven’t experienced any side effects. Easy to administer with clear instructions.
Lazara Vila –
Your review *
Jessica Bowers –
Not too sure, it’s been two weeks. Haven’t seen any change. I get dizzy now, periodically. I feel like I get full or bloated feeling faster after eating but I’m still hungry. Didn’t curb appetite or cravings.
Alicia Alexander –
Your review *
Erica Towner –
Jennifer –
I appreciate the prompt response to any questions I have. Ordering is always easy and the product arrives in timely fashion.
Tina –
Very quick turnaround time, and responsive customer service. The instructions are very clear, and the process of injection is easy. I have taken three doses and have noticed a difference in my hunger levels and have lost few pounds!
Lisa –
I am losing weight, my blood pressure is down and I feel great after only 3 weeks on the starting dose of Semaglutide! I feel I have a new lease on life. I eat smaller portions, I don’t think about food between meals and I feel less bloated.
Marta DaSilva –
unfortunately it didn’t help me at all.
Kim Pagoto –
Leon Carpenter –
Gerald Fette MD –
I’m a new customer/patient and a practicing physician. My experience with your organization has been great. Thank you for making the medication available to me without the usual red tape.
THERESA MCKAY –
Fast! Easy! Safe! Great experience! I highly recommend working with VITAstir, and am grateful for this option to help me with my weight loss journey!
Maria Largaespada –
Autumn W. –
Extremely fast service! Highly recommend!!
Anonymous –
It works great!
Anonymous –
Glen Hoard –
Your review *
Laura –
Anonymous –
So far so good! Have done 3 doses of first month and have had no negative side effects !!
Jean –
Very easy and informative consult
Anonymous –
The process was easy and I received my order on time. Instructions were easy to follow and I’m very happy with my results. I noticed on the first week that my cravings and appetite were under control.
Claire Cross –
Laura H. –
I’m so pleased with everything I have ever ordered. Super quick and timely services.
Anonymous –
I have been using this product for 2 weeks so far. It’s been wonderful. My appetite has decreased and I have lost an inch around my waist already. Also no side effects at all except for feeling a tiny bit tired the first day. I have been more motivated to exercise because I’m seeing results and I want to maximize weight loss. This product is a game changer
Eric P. –
Just started with the first month but already seeing results. Also, very easy transaction and shipping was super fast.
Anonymous –
Incredible product and company!
Lana –
Exceptional service so easy to order, beautiful packaging finally an honest company and prompt delivery!
Viktorija –
Finished my first month and feeling good. 5lbs down and minimal side effects besides surprised appetite
Paula Ferguson –
Cheryl –
I’m into my first month. I’m happy there are no side effects. The communication at Vitastir is excellent. My questions and concerns as a new patient has been spot on and I’m eagerly anticipating the months to come.
kristina dobrijevic –
Great product
Claire Meisinger –
Deborah Cuffaro –
Pamela –
Works immediately. No desire for sweets, potato chips, sugary drinks. Engery and wanting to exercise (love walking) Hard to obtain under other circumstances, however, the price and speed of delivery I am thankful for.
Brandi –
Amazing product went down 6 pounds one week!
Blake Shephard –
rhonda –
Just started using it but i’m already down 5 pounds
kim –
Already 6 lbs down. Looking forward to shedding more of this weight.
Anonymous –
Edwinna Vanderzanden –
Shelly R. –
Came promptly and packaged well, easy to order
Raquel –
This stuff is truly amazing! It took about 2 to 4 days after the 1 week’s shot for me to start to feel any changes. It literally took my hunger away completely! Also took away any cravings and it gives my really good energy. I have tried to lose all the extra weight I put on during Covid (about 30lbs) and nothing has worked well as this. I exercise 3-4 times a week but it’s very hard for me to diet because I’m hypoglycemic. With these injections I feel extremely in balance, no hypoglycemia at all, and no jitters. Im on my third week now, and o already lost 8lbs!
I have not experienced any nausea, or any negative side effects as described. This is a real miracle shot!
Leisa G. –
Helps with your energy and curves your appetite. Would recommend to family and friends.
Anonymous –
Incredible customer service. I have contacted them many times with questions and they are as nice as can be and so helpful. I will continue to order, and have had great results.
Anonymous –
Tammy T. –
No jitters and down 4 pounds the first month
TRAVIS S. –
Good product. Controls appetite. Also energy level is higher
Terri Acklin –
Very hard to get medicine out of vial
Marvin Gunn –
Kayla Reveal –
Heather mayer –
Your review *
Anonymous –
Jennifer Hamilton –
I had my first dose 1/7/2023 and as of 1/12/2023 I’m down 8lbs. This is combined with intermediate fasting, a low carb /calorie intake and with a lite workout regimen 3 times a week for 30 minutes. I’m flabbergasted with my results 🙂 in week one. I have a weight-loss goal of 50lb by June , I don’t think I’ll have a issue getting there with this little miracle ;).
Betty Shively –
Your review *
Carrie Bowen OBryant –
Nice info
Name * –
Interested
Talisha Rodgers –
Done
Krista Cipollone –
I just started but after my first injection I’m happy to report I got zero of the negative side effects that can happen. Perhaps it’s because of how they mix it with b12? Also great customer service
Vicky Grigsby –
Dec 30. 2022
Sara Sierra –
Your review *